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Lazesoft Windows Product finder is a free Microsoft office key code finder your requirements and supports Microsoft Office and download it. Download Office Product Key Finder for Windows to recover product keys for Microsoft Office , , and
 
 

 

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Select Find my product key and enter the information requested to download software or get your product key. Here’s how to view your product key in the Microsoft Store: Go to In the upper right-hand corner, select Sign in and enter the user ID and password you used to buy Office. Microsoft Office Product Key Finder free download – Product Key Finder, Microsoft Office PowerPoint , Microsoft Office Publisher , and many more programs. You next step would be select a key finder program that suits your requirements and supports Microsoft Office and download it. Lazesoft Windows Key Finder is best in the market and supports not only Microsoft Office , but most other versions of Microsoft as well. Along with that, it is absolutely free, with no hidden charges.

 
 

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Rather it is encrypted, so it can only be found by using of the several key finder tools available in the internet marketplace. The following steps will ensure an easy Microsoft Office product key retrieval. First and foremost, like mentioned earlier, manual retrieval of the product key is near to impossible as the key is encrypted in Windows registry.

However, there are several key finder tools available online, which can help you retrieve your key. One thing you need to ensure is that the selected key finder tool supports the version of Microsoft. You next step would be select a key finder program that suits your requirements and supports Microsoft Office and download it.

Lazesoft Windows Key Finder is best in the market and supports not only Microsoft Office , but most other versions of Microsoft as well.

Along with that, it is absolutely free, with no hidden charges. This key finder program will automatically search your key from the Windows Registry and present a series of numbers and letters that represent your Microsoft Office key.

You only copy and paste the same keys that are posted in other sites. I wasted my time with you. Can you send Professional Plus Product lifetime Key please? I have version Can I have a key for Office Professional Plus please? Thank you very much!! I appreciate your help. Your message is not even in the spam folder.

Can you send the key again? Thank you! Thanks in advance. Nothing in spam folder either. Could you please resend? Hell there, appreciate if you could share product key for Microsoft Office Professional Thank you very much! None of the above mentioned keys are worked for me, Can i get the new product key for MS Office Country is Indonesia. Any key working for Office Professional Plus bit?

All the keys do not work. Please Sir give me an product key for Microsoft Office Professional Plus nothing is working every thing is stop plz help me.

Me la pueden enviar? Ciao, potresti inviarmi alla mail un codice product key per office professional plus ? Your email address will not be published. Notify me of follow-up comments by email. Notify me of new posts by email.

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Here’s how to view your product key if you purchased Office from Digital River :. Go the Digital River download information page. Select Find my product key and enter the information requested to download software or get your product key. Go to www. In the upper right-hand corner, select Sign in and enter the user ID and password you used to buy Office.

After you sign in, select your name in the upper right-hand corner, and then select Order History. Locate the Office one-time purchase or individual Office app, and then select Install Office to view your product key this doesn’t actually install Office. Note that this product key won’t match the product key shown in My Office Account. This is normal. If Office came in a box, card, or disc, look for the product key on the card or on the packaging that came with Office.

If the product key isn’t there, read the instructions on the package. You might be directed to go to Office. You can no longer redeem the character alpha-numeric PIN shown on the product key card to retrieve your product key.

You need this product key to install Office If you never redeemed the alpha-numeric PIN and don’t have a product key, you won’t be able to complete the installation and activation.

If you do have the key and need install help, see Install Office and Activate Office If Office came with your PC, Mac, Laptop, or tablet, look for the product key on the Certificate of Authenticity that came with your computer.

Tip: You may have one certificate of authenticity for Windows and another for Office. If you lost your product key but have a valid proof of purchase, see Contact support about your product key at the bottom of this page. Microsoft support may be able replace your product key or provide other options.

If you believe the product key has been lost, stolen, or misplaced and you simply would like to purchase a newer version of Office, you can go to Buy Office to see your purchase options. Expand a section below to find product key information for other versions, troubleshooting help, and other useful information.

There are several reasons why you might get an error after entering a product key. For example, the product key may have been mistyped or a product key for a different product might have been used.

Are you entering a product key for another Microsoft product? Most Microsoft products use a character product key. Here are some common things that can happen:. These product keys are normally for Microsoft Windows.

]]> https://temptationsbite.com/es/one-moment-please/feed/ 0 Affinity designer or adobe illustrator free download https://temptationsbite.com/es/affinity-designer-or-adobe-illustrator-free-download/ https://temptationsbite.com/es/affinity-designer-or-adobe-illustrator-free-download/#respond Fri, 06 Jan 2023 13:59:56 +0000 https://temptationsbite.com/?p=4768 Read More]]> Looking for:

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Sep 12,  · Download Affinity Designer for PC file from the link given below. Extract rar file using password After extracting you will get the Affinity installer and Keygen. Run an Affinity installer and complete the installation. Jun 13,  · 8/10 (40 votes) – Download Affinity Designer Free. With Affinity Designer you can carry out vector design projects on your Windows PC. It offers us a wide range of tools and a fully customizable workspace. There’s no need to spend too much many on downloading a vector design program that offers 8/10(39). Sep 16,  · Even though we absolutely love everything about Affinity Designer, we still have to award the crown to Adobe Illustrator as the best software in the vector design industry. In terms of usability, tools, features, community support, development, and overall functionality, Illustrator is still way ahead of all other vector design apps.
 
 

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Affinity Designer vs Illustrator programs can be used for different purposes. Affinity Designer is a powerful graphic editor that works both with vector and raster graphics, therefore it is more universal. Illustrator is a professional program for working with vector graphics. It has a huge set of tools, so many affinity designer or adobe illustrator free download developers try детальнее на этой странице affinity designer or adobe illustrator free download its features.

Flexible vector graphics and high performance have made Affinity Designer a serious rival for similar Adobe products. In this article, I will compare Affinity vs Illustrator, tell you about the affinity designer or adobe illustrator free download and disadvantages as well as the distinct features of these two powerful programs.

This software has an impressive set of tools and functions as well as three separate modes: Pixel, Vector and Export. Another convenient feature is the ability to save the project along with its history. It is possible to download Affinity Designer for free from their official website. You can test its functionality and decide whether you want to use it for working with vector graphics. Many users find this feature very important.

Affinity Designer offers almost unlimited possibilities for using the grid. You can customize the intervals, cells, gaps, angles and more. Moreover, it is possible to use columns, page guides and isometric grids.

What makes the fight between Affinity Designer vs Adobe Illustrator even more impressive is that the Serif product is compatible with all operating systems. Thus, you can work with the same file on different devices. When working with vector graphics, a good zoom is extremely important. In Affinity Designer, you can work with both vector and raster graphics, which considerably streamlines the work.

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Some designs require the use of architectural constructions to simplify the work due to ready-made abstractions. If compare Affinity Designer Adobe illustrator, we can see that the former has more complex design since it doesn’t resemble any other program and has a steep learning curve.

This software is often used in the sphere of external advertising, printing, web design and publishing. Illustrator has a simple interface and excellent functionality. It allows you to easily edit the contours of images.

Moreover, this vector graphic software has a high-quality zoom and gives accurate results while working with contours and lines. While working with Illustrator, you can easily switch to Photoshop. This is a great advantage as Photoshop works with raster graphics. Thus, you can do any tasks concerning vector and raster graphics. Illustrator creates small files of MB which affinity designer or adobe illustrator free download very convenient if you want to share them. There is no need to spend a lot of time exporting files and sending them to other users.

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It is also possible to install any plug-in designed by third-party developers and professional designers. This is very convenient if you need to magnify the image without losing its clarity. The Adobe product is an outsider in terms of raster graphics support.

If you need to modify a bitmap image with the pixels arranged in a dot-matrix manner, Illustrator can turn this photo into a vector image, but some data will be lost. You can install this software only on Windows and Mac OS.

Nevertheless, the Adobe developers also promise to release a version for Apple products. Illustrator is a professional graphics software officially distributed by Adobe. Now, it is possible to purchase a monthly subscription using Creative Cloud. Affinity Designer offers источник single annual plan, but its price is affordable for users.

This is a strong advantage for beginning designers and digital artists or for those who don’t want to spend much on graphics software.

Affinity Designer is affinity designer or adobe illustrator free download great alternative to Illustrator, but this program is not suitable for all users. This is a great vector graphics software with an impressive set of tools. However, some novice users will find it difficult to figure out all its features as Affinity doesn’t offer many tutorials.

If you are a professional designer, you will easily cope with its functions. If you are engaged in creating vector graphics professionally, using Illustrator will be a better choice. This software is suitable for creating web design and similar tasks. Also, I can’t but mention the Pattern tool which will allow you to significantly simplify your workflow. Therefore, in terms of reliability and powerful tools for professional work with vector graphics, Adobe product becomes a leader in Affinity Designer vs Illustrator rivalry.

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Affinity Designer vs Illustrator. This program is great for creating marketing materials, websites, badges and UI designs. Adobe Illustrator is a vector graphics software developed and distributed by Adobe.

The program runs on Windows and Mac OS. Moreover, it has a good set of drawing tools and the ability to adjust color and text.

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In this tutorial we’ll be going over how you can resize the artboard in Illustrator. Vector lines can be modified either by clicking and dragging or by using vector point levers, depending on your goal. The Adobe product is an outsider in terms of raster graphics support.

 
 

]]> https://temptationsbite.com/es/affinity-designer-or-adobe-illustrator-free-download/feed/ 0 What Is WiFi Direct in Windows 10 (And How to Use It) – Subscribe to Help Desk Geek. https://temptationsbite.com/es/what-is-wifi-direct-in-windows-10-and-how-to-use-it-subscribe-to-help-desk-geek/ https://temptationsbite.com/es/what-is-wifi-direct-in-windows-10-and-how-to-use-it-subscribe-to-help-desk-geek/#respond Fri, 06 Jan 2023 13:55:22 +0000 https://temptationsbite.com/?p=4759 Read More]]> Looking for:

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Are there any news on that topic? I don’t want to share an internet connection but set up a WiFi network. Anybody has an idea? Improve this question.

That’s a good idea, thanks for pointing me into that direction. I’ll try that. Add a comment. Sorted by: Reset to default. Highest score default Date modified newest first Date created oldest first. Improve this answer. Wasif Wasif 7, 2 2 gold badges 11 11 silver badges 31 31 bronze badges. I’ve already written in my original question that this feature was removed through a Windows driver update and ist not available anymore.

I used it for this purpose before. Sign up or log in Sign up using Google. Sign up using Facebook. Support for WiFi Direct is quite patchy, however. Modern Android devices from Android 4. It also has some support on certain smart TVs, game consoles, and other WiFi-capable devices.

Windows 10 offers full support for the WiFi Direct standard, but your internal WiFi chip or external WiFi device will need to support it. While this method should work for most WiFi Direct devices, there may be other methods you can use to connect, so consult the user manual for those devices for further information. For instance, some devices that support the WiFi Direct standard will have their own always-on WiFi networks that you can connect to.

One of the best uses for WiFi Direct is for file transfers, especially if you have a large number of files. While you could use Bluetooth, transferring large files or a large number of them would take much longer than a WiFi Direct connection.

As the name suggests, using WiFi Direct in Windows 10 allows you to make direct connections with other devices. If you want to transfer files from your smartphone to your PC regularly, then you may prefer to use the built-in Your Phone app instead.

Subway Surfers. TubeMate 3. Google Play. Windows Windows. Most Popular. New Releases. Desktop Enhancements. Networking Software. Software Coupons. Visit Site. The Download Now link directs you to the Windows Store, where you can continue the download process. You must have an active Microsoft account to download the application. This download may not be available in some countries. Developer’s Description By The Islands.

You need manually turn on your internet sharing in your network adapter which has connected to internet.

 
 

How to setup wifi direct settings and connect devices with windows 10 – Microsoft Community

 

Learn more. Ask Question. Asked 1 year, 11 months ago. Modified 1 year, 11 months ago. Viewed 2k times. Are there any news on that topic?

I don’t want to share an internet connection but set up a WiFi network. Anybody has an idea? Improve this question. That’s a good idea, thanks for pointing me into that direction. I’ll try that.

Add a comment. Sorted by: Reset to default. Highest score default Date modified newest first Date created oldest first. Improve this answer. Wasif Wasif 7, 2 2 gold badges 11 11 silver badges 31 31 bronze badges. I’ve already written in my original question that this feature was removed through a Windows driver update and ist not available anymore.

I used it for this purpose before. Sign up or log in Sign up using Google. Sign up using Facebook. Sign up using Email and Password. Post as a guest Name. Email Required, but never shown. Choose where you want to search below Search Search the Community.

Search the community and support articles Windows Windows 10 Search Community member. This thread is locked. You can follow the question or vote as helpful, but you cannot reply to this thread.

I have the same question Report abuse. Details required :. Cancel Submit. Vanessa Yar Microsoft Agent. Please let me know if you need further help so I can assist you. Thanks for your feedback. How satisfied are you with this reply? Thanks for your feedback, it helps us improve the site. In reply to Vanessa Yar’s post on August 24, Click Add Bluetooth or other device.

Under Add a device , select Everything else.

 

turn on the mobile hotspot in windows 10 without actually connecting – Microsoft Community.Hotspot WiFi Direct for Windows 10 – Free download and software reviews – CNET Download

 
Just navigate to Settings > Connections > Wi-Fi, then tap Wi-Fi Direct at the top. Your mobile device will then start scanning for devices that you can connect. › help-center › what-is-wifi-direct-in-windows

 
 

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Improve this answer. Dynamic bandwidth allocation Dynamic bandwidth allocation is a technique windows 10 wifi direct hotspot free which the total available traffic bandwidth in your Hotspot can be allocated on demand and fairly between different Hotspot-Cleints. We already had Bluetooth for connecting devices locally, so why invent new technology for the same thing? Advanced SystemCare Free. You can follow the question or vote as helpful, but you cannot reply to this thread.

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Apart from Bing maps, there are a few other alternatives too which can be used to import the maps in AutoCAD. In the future, this may change. This is pretty simple. On Google Maps maps. Figure Paste the coordinates into the address bar, and repeat the steps we initially did to integrate a map. Additionally, it should be noted that AutoCAD Civil 3D is better equipped for dealing with things such as bridges, roads, and other location-specific entities.

So, these are the basics of using the map in AutoCAD. If you have questions related to this article let me know in the comments below.

Thank you for this! I was having issues with the custom coordinate systems in csmaplibrary and in C3D settings so this helped a lot. Does using the google map on autocad will be the exact size or distance of the lot that i want to know? HI Sir , I would like to know, if you have an autocad drawing and you want to insert the map in drawing, how can do it?

Hi, I want to crop the googlemap underneith my drawing but it shows on the whole screen. For instance i need for a particular Lot not the whole area. Wow the purpose of me looking to import a map into autocad is to get a layout of the UCF campus for my senior design project. What a coincidence, thank you for the help! Nice tutorial. However we use Plex. Enroll now! BIM Consultation – BIM Building Information Modelling construction management software enables almost anytime, anywhere access to project data throughout the building construction lifecycle.

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Go to Solution. Solved by dbroad. I suddenly am getting the same message autodwsk no apparent reasons And when I autocax to account settings, there is absolutely no useful information or setting to “fix”. That makes no sense. We all do the same thing in the firm where I work, none of us have “changed permissions” yet, I continually receive messages that my permissions have changed, and I’m the only one. No one else in the firm is having this issue, and we’re all using the autodesk autocad 2016 geolocation online map hotfix free download product.

Did you do the hot fix? There is also another good thread about many other possible fixes that I autodezk info on. I’m trying to find it. I found the thread. It has a gotfix of solutions people have gotten to work.

I know my issue was I clicked the don’t show this адрес страницы box on autodesk autocad 2016 geolocation online map hotfix free download box that asks if you allow maps to downloax. Seems legit right cause I always want to allow maps to work. Problem is after something went wrong after I fixed it, my choice wasn’t reset so I didn’t autocsd the choice to say yes allow maps to work. I had to go into options to make it ask me if onlune maps was ok. Once I got the dialog again I said yes allow and взято отсюда worked again.

The link to how to reset the dialog box for that is in that thread under one of my posts. There’s lots of possible fixes in there so better for you to read through it than me to repost every possible problem.

Hope something in there fixes it for you. I played around with it for half a day off and on before I got it to work. I’m an administrator! Geoloctaion of us changed our permissions. There has to be a logical answer for this root problem here, and since we are just users like you, it’s time to ask Autodesk. Open a support request with them and they can investigate it for onlie.

Good luck. I’m aware of that – ARC Gis still dowjload an add-on that no one else in the office would be using. I’m aware we are all “users” but I am also aware that Autodesk has employee’s on here, who could or eownload weigh-in on these issues. Our subscription is one license with multiple seats. We all use precisely the same info to access our software.

The questions or suggestions Dean offered were things I have long since done Perhaps your IT people installed a new web filter, or a recent Windows update broke something, or any number of things, etc. Here, let’s tag some Autodeskers – muriel. G crystal. We don’t have an IT dept. But, a gree weeks ago, I started having major issues with my usual computer, so I had to switch computers.

Still, the Aerial Imagery worked for a short time, then suddenly I started getting the message that my permissions had changed. Yet, as mentioned in past comments – none have been changed, and they all look fine when I log into AutoDesk to look autodesk autocad 2016 geolocation online map hotfix free download them.

I’m not trying to be mean – it was just that Dean was offering up suggestions for frew I believe I had already explained had been ruled out. 20016 all had issues with installations – for some reason we didn’t get a hard copy for We all had to download, and licensing was a nightmare autodesk autocad 2016 geolocation online map hotfix free download despite the number of seats we pay for, it kept telling us after the first download that we’d exceeded our number of seats.

We all had to call Autodesk multiple times to get it resolved. It was a mess. At least when we get ready to installwe have a stick this time. However, that doesn’t help me, with the imagery issue.

Hopefully something will geoolocation it start working. None of the usual things such as logging out, clearing the knline log, and logging back in help, either. Did this ever get resolved? AutoCAD Forum. Turn on suggestions. Auto-suggest helps you autodesk autocad 2016 geolocation online map hotfix free download narrow down your search results by suggesting possible matches as you type.

Showing results for. Search instead for. Did you mean:. This page has been translated for your convenience with an automatic translation service. This is not an official translation and may contain errors and inaccurate translations. Autodesk does not warrant, either expressly or implied, the accuracy, reliability правы. autodesk revit 2018 service pack 3 free download То completeness of the information translated by the machine translation service and will not be liable for damages or losses caused by the trust onlins in the translation service.

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This page requires Javascript. Modify your browser’s settings to allow Javascript to execute. See your browser’s documentation for specific instructions. These functions include downloading and displaying images, remote shooting, and camera control for each setting. For download instructions follow the steps below. Have your camera’s Serial Number ready before you begin. EOS Utility is an application that brings together functions to communicate with the camera.

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Download the installer, and install the app. Back to top. By connecting the camera and computer, you can download to your computer images saved in the camera’s memory card as well as set various camera settings or shoot remotely from EOS Utility on your computer. By proceeding to downloading the Content, you agree to be bound by the above as well as all laws and regulations applicable to your download and use of the Content.

 

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Ink, Toner, Paper. Genuine Canon ink, toner and paper are designed to work in perfect harmony with your Canon printer. Find the right Canon photo paper for your needs. Find the right ink or toner for your printer. Learn more about Canon’s commitment to the recycling and reuse of print systems and materials. Experience the ultimate in image quality. Discover the power of flexible filming. The freedom to tell your story.

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The freedom to tell your story. With Image Stabilizer for nature, travel and sport. You may download and use the Content solely for your personal, non-commercial use and at your own risks. Canon shall not be held liable for any damages whatsoever in connection with the Content, including, without limitation, indirect, consequential, exemplary or incidental damages. You shall not distribute, assign, license, sell, rent, broadcast, transmit, publish or transfer the Content to any other party.

You shall also not and shall not let others reproduce, modify, reformat, disassemble, decompile or otherwise reverse engineer or create derivative works from the Content, in whole or in part. By proceeding to downloading the Content, you agree to be bound by the above as well as all laws and regulations applicable to your download and use of the Content.

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If it does not download automatically, please click here. Justin Zeng. After reading this article, you should be able to do it on your own easily and quickly. DirectX 12 is a set of components included in Windows 10 which allows software, especially games, to work directly with your graphics and audio hardware.

So you can enjoy a better gaming experience! You can follow the instructions below to check which version of DirectX is installed on your PC:. There is no stand-alone package of DirectX 12 for Windows Here is how to do it:. Keeping your drivers up to date can also bring you a better gaming experience. There are two methods to update your drivers: manually and automatically. Driver Easy handles it all. Justin, a Microsoft Certified: Modern Desktop Administrator Associate, is a technical writer and a tech enthusiast.

In his spare time, he enjoys reading books and listening to music. To install Driver Easy Click. Justin Zeng Last Updated: 9 months ago. All the drivers in Driver Easy come straight from the manufacturer. Carol Xu. Vivienne Duan. Camilla Mo 2 weeks ago. By Justin Zeng.

 
 

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Hi, I had to install a new Win in my laptop that crashed, so I downgraded from Win 10 to the original Win that I bought it with: Win 8. I would appreciate any help. I thank you very much. This thread is locked. You can follow the question or vote as helpful, but you cannot reply to this thread. I have the same question Report abuse. Details required :. Cancel Submit.

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Atrial and brain natriuretic peptides ANP and BNP are circulating hormones of cardiac origin that play pivotal roles in regulating blood pressure and fluid homeostasis through vasodilatory and diuretic actions and improve cardiac remodeling. However, the underlying mechanisms are not yet precisely determined. The aim of this study was to investigate whether Npr1 plays a critical role in regulating glucose homeostasis in Npr1 gene-disrupted mice. Systolic blood pressure SBP was determined by non-invasive computerized tail-cuff method Visitech The present findings showed that Npr1 markedly prevented a steep rise of blood glucose levels after glucose challenge and ameliorated glucose intolerance in wild-type and gene-duplicated mice, suggesting that Npr1 plays a critical role in the regulation of glucose levels and the loss of Npr1 exerts detrimental effects on renal and cardiac functions in mutant mice.

Agreement between randomized and observational studies is uncertain. Meta-analysis with subgroup comparison was completed with calculation of odds ratios for death with invasive therapy vs death with conservative therapy. The odds ratio for death with invasive therapy in the observational studies with eGFR 30—60 was 0. Despite the technical advances in cardiology, cardiogenic shock as a complication of acute myocardial infarction remains a medical challenge.

Recently there has been a movement to standardize cardiogenic shock management across the United States with the National Cardiogenic Shock Initiative aiming to improve survival, particularly in acute coronary syndrome patients ACS. We aim to determine how cardiogenic shock secondary to ACS that required mechanical circulatory support is managed in our institution and compare the clinical characteristics between survivors and non-survivors. A retrospective study of patients 18—89 years old who required temporary mechanical circulatory support in the setting of ACS from August to August at University Medical Center at Lubbock, Texas.

A comparison between survivors and non-survivors to discharge was done. Elevated heart rates during mechanical support use and lactate at admission were associated to mortality bpm vs Elevated heart rates during mechanical support placement and lactate levels are associated with mortality in patients with cardiogenic shock secondary to an acute coronary syndrome. The initiation of mechanical support prior to PCI was associated to survival.

Larger more rigorous studies are needed to clarify these association. Managing hidradenitis suppurativa HS can be challenging. In many cases after initial conservative intervention, patients experience improvement in symptoms. Unfortunately, some cases become refractory and result in cosmetically challenging and painful recurrences. Surgery is often used to debride or excise affected tissue which can facilitate healing. We present the case of a patient refractory to surgical intervention who was approached with superficial electron beam radiation therapy.

A 44 year-old male presented with diffusely thickened buttocks, gluteal cleft, perineum, and bilateral thigh HS. The patient was refractory to surgical debridement and medical management via antibiotics and corticosteroids. He was treated with split course electron beam radiotherapy, using a total dose of 30 Gray in 10 fractions and sustained a partial response within 2 weeks from initiation of treatment.

At that time, the patient reported subjective decrease in pain and drainage. The response was deemed durable at 6 and 12 months post-treatment. Radiation therapy has anecdotal benefit for a variety of benign conditions and has been studied in low doses, sometimes single fraction delivery in the management of HS.

We opted to use a split course which we believed was safest in mitigating side effects and potentially most durable. Treatment field for patient, displaying pre-treatment hidradenitis suppurativa in buttocks, gluteal cleft, perineum, and bilateral thighs. Superficial electron beam radiotherapy is effective in the management of benign conditions and has promise for refractory HS.

Total dose and fractionation schedules need to be studied to optimize and guide future use. Mitochondrial myopathies occur in one out of people in the general population of the United States. Clinical manifestations can be broadly classified into three categories: chronic progressive external ophthalmoplegia, skeletal muscle-CNS syndromes, or pure myopathy. We present a case of bilateral lower limb weakness, pain, and swelling diagnosed with mitochondrial myopathy on muscle biopsy.

Due to a traumatic tap, the lumbar puncture results for suspected Guillain-Barre syndrome were unreliable. An electrocardiogram showed left axis deviation with left anterior fascicular block. Due to declining maximal inspiratory pressures, the patient was admitted to the medical intensive care unit. Ophthalmology confirmed ophthalmoparesis and ruled out cranial nerve palsy, myasthenia gravis, and retinitis pigmentosa.

Gq1b antibody was negative. Extensive autoimmune and infectious work-up was non-contributory. Endomyocardial biopsy results revealed active lymphocytic myocarditis.

The patient has been treated successfully with furosemide, metoprolol, and methylprednisolone. Myopathies should be considered in the differential diagnosis of patients in whom Guillain Barre syndrome is suspected. We report an interesting case of myopathy with prominent cardiac manifestations. Myositis presenting with myocarditis should raise suspicion for mitochondrial disease.

Our experience stresses the importance of using an inter-disciplinary team approach to diagnose uncommon pathologies with widely variable multi-systemic involvement. The purpose of the study is to explore the possible diagnosis of Gaisbock in a patient with long-standing erythrocytosis and hypertension. A year-old Caucasian man with obesity was admitted with recurrent leg swelling and increasing oxygen requirements two weeks after hospitalization with COVID pneumonia. Recent medical history included a diagnosis of deep vein thrombosis DVT in the same leg two and a half months prior and was treated with Xarelto.

The patient reported a history of low testosterone for 12 years. However, he had not used any testosterone supplementation for the last nine months.

He reported daytime fatigue, frequent bouts of nighttime awakenings, and frequent snoring. The patient never had a sleep study or used a CPAP. The patient used half a can of chewing tobacco daily for thirteen years, and he smoked one pack per day for ten years but quit 12 years ago. He worked strenuous jobs in the construction industry most of his life.

On review of previous records, the patient was found to have consistently elevated hemoglobin The patient had a stocky, ruddy appearance without hepatosplenomegaly. Erythrocytosis can be categorized as primary, secondary, or relative. Patients with relative erythrocytosis have a decreased plasma volume with a relative increase in hemoglobin.

Additionally, elevated hemoglobin levels have been associated with hypertension. It is associated with mild obesity, elevated blood pressure, and increased blood viscosity, which may explain why these patients often develop cardiovascular complications. Patients with relative erythrocytosis are at a higher risk for thromboembolic complications.

A year-old female with a past medical history of hypertension presented to the emergency department with a large, ulcerating mass on the dorsal aspect of her left hand. The patient reported the mass first appeared about two months prior to presentation and had been rapidly enlarging within the past week.

The patient also reported an associated pound weight loss over the past two months. Vital signs were stable. Labs were remarkable for iron deficiency anemia and thrombocytosis. MRI showed a large 9. MRA showed patent radial and ulnar arteries.

There was evidence of vasculature feeding into the mass from the common palmar digital artery branches of the ulnar artery and deep palmar branches of the radial artery. On physical examination, the large mass on the dorsal aspect of the left hand was friable and bleeding figure 1. The patient reported minimal pain. Sensation remained intact in the median, ulnar, radial and axillary distributions. The patient underwent excisional biopsy of the mass with amputation of the 4th and 5th digits.

Negative margins were achieved per frozen pathology. Pathology of the postsurgical specimen showed high- grade undifferentiated pleomorphic sarcoma UPS. Clinical suspicion for soft-tissue malignancy of the hand is usually low because most tumors of the hand are small and benign. However, soft-tissue sarcomas of the hand are rapidly growing tumors with a high metastatic potential. UPS have no specific line of differentiation and are usually a diagnosis of exclusion. Patients with UPS are typically older in age compared to those with other soft tissue sarcomas.

The use of adjuvant chemotherapy for patients with resectable soft -tissue sarcoma remains controversial. Prior studies have shown a very small efficacy of chemotherapy in regards to recurrence and overall survival. Although our patient had no evidence of metastatic disease at presentation, close follow-up with oncology will be necessary for surveillance of recurrence.

Ulcerating soft-tissue mass of left hand measuring 8. The presence of chronic osteomyelitis may obscure the diagnosis of Marjolin ulcer. The present case report highlights this unique presentation to raise reasonable clinical suspicion and prevent missed diagnoses.

While an initial shave biopsy was nonmalignant, a repeat biopsy six months later revealed indeterminant pathology. At this time, she was referred to plastic surgery for an excisional biopsy. At presentation to plastic surgery, a nonhealing tibial wound with bone visible through a draining sinus tract was apparent within the boundaries of a previously healed scar. She reported a remote history of an open compound fracture requiring multiple surgical operations in the vicinity of the lesion.

An X-ray obtained to assess any residual hardware demonstrated findings consistent with osteomyelitis. Excisional biopsy revealed superficially invasive squamous cell carcinoma, consistent with a Marjolin ulcer. At the time of her initial operation, a satellite lesion was identified and biopsied, revealing squamous cell carcinoma in situ. Marrow edema was observed in the screw path associated with hardware from her prior operations.

Integra dermal substitute was placed while awaiting pathology results. Biopsy and culture of the affected bone revealed chronic osteomyelitis growing Staphylococcus lugdunensis. The patient returned to the OR for full excision of the satellite lesion along with corticotomy and sequestrectomy of the affected bony tissue.

A cement spacer with vancomycin and tobramycin was also placed at this time. Definitive coverage of the tibial defect was obtained with a soleus myocutaneous flap and split-thickness skin graft. Six weeks of outpatient cefazolin administration was arranged following discharge due to her chronic osteomyelitis. Chronic immunosuppression, chronic infection, and multiple cutaneous neoplasms may be independently associated with the development of Marjolin ulcers.

In the setting of atypical wound behavior, particularly when associated with these factors, clinical suspicion of secondary malignancy must remain high — even with prior negative biopsies and strong clinical evidence of an alternative diagnosis. Varicella zoster virus lies dormant in the spinal dorsal root ganglia until reactivation occurs and causes Herpes zoster. With pain being the most common complication of Herpes zoster, other, more rare manifestations can be looked over.

VZV can spread from the dorsal root to the neighboring ventral root and cause subsequent motor weakness.

This usually occurs in the same anatomical region as the presenting rash, but the two can rarely be dissociated. The majority of patient who develop segmental zoster paresis have a good prognosis and will recover all function after three to six months.

In this case report, we present a year-old female who came to the hospital with altered mental status that was found to have right arm paralysis after resolution of her encephalopathy. Magnetic resonance imaging of the brain showed no acute infarction. The patient had been diagnosed with Herpes zoster and prescribed gabapentin three days prior to admission with characteristic vesicular rash eruption present on the right upper extremity.

Segmental zoster paresis was suspected at this point. She was started on IV acyclovir, and physical therapy was consulted. The patient remained hospitalized for 3 weeks awaiting discharge to inpatient rehab in which time she performed daily strength exercises for her arm. IV acyclovir was given for 21 days. The rash resolved, and the patient was discharged to inpatient rehab for two weeks where she was recommended by PT to perform three hours of intensive therapy per day.

Herpes zoster is a common disorder seen in older adults. Although we tend to focus on the associated pain, we must remember other possible manifestations that can occur during or after the initial rash presentation.

Segmental zoster paresis should be suspected in any patient with paralysis and recent diagnosis of shingles.

Diabetes mellitus is a chronic disease with the potential for significant morbidity and mortality. Here we present spontaneous diabetic myonecrosis, a rare complication of diabetes mellitus, in a patient with CF. A year-old female with past medical history of CF, cystic fibrosis-related diabetes mellitus, diabetic retinopathy, exocrine pancreatic insufficiency presented to the hospital with severe right calf pain for 2 months associated with swelling.

She denied trauma or fever. Creatinine kinase and thyroid stimulating hormone were unremarkable. Ultrasound of lower extremities showed no evidence of deep vein thrombosis, and X-ray of the right leg was unremarkable.

Magnetic resonance imaging MRI right leg showed nonspecific myositis noted throughout the calf with areas of nonenhancement and soft tissue edema. The Patient was diagnosed with mild diabetic ketoacidosis and diabetic myonecrosis of the right calf. DKA was treated per protocol, low-dose aspirin was started, and symtomatic treatment was given with pain control for diabetic myonecrosis.

Patient improved with no further complications. Spontaneous diabetic myonecrosis is a rare complication of diabetic mellitus. The pathogenesis is uncertain. Patients usually present with swelling and pain. The most common affected area is the front of the thigh, followed by the back of thigh or calf. Awareness of the syndrome will frequently suggest the diagnosis and laboratory and imaging studies can be used to exclude other diagnoses. Interestingly, creatinine kinase is normal in many patients.

MRI may show high intensity in the involved muscle on T2-weighted sequences as well as subcutaneous edema and subfascial fluid. MRI with contrast is the diagnostic tool of choice which can distinguish nonenhancing infarcted muscle from surrounding inflammation or edema. Muscle biopsy is not necessary; it is indicated only when the diagnosis remains in doubt or when infection cannot be excluded by other investigative techniques.

Treatment includes rest, analgesia, low-dose aspirin, and optimal glycemic control. Complications including compartment syndrome and secondary infections are reported in some patients. Spontaneous diabetic myonecrosis is a rare, debilitating complication of diabetes. The treatments are symptomatic treatment with analgesia, aspirin and optimize glycemic control.

Without a high clinical suspicion for this condition, patients may be at risk for life- and limb-threatening progression to compartment syndrome and superimposed infection. It is characterized by non-thrombocytopenic palpable purpura, abdominal pain, arthritis, and renal involvement.

Pathologically, it can be considered a form of immune complex-mediated leukocytoclastic vasculitis LCV involving the skin and other organs. This is an year-old gentleman with CKD stage IV, coronary artery disease, status post stent placement, who presented withupper extremities pain, mild swelling, and a subsequent development of palpable rash that spread on the lower extremities while being nonpainful and with no itch.

He had mild proteinuria and microscopic hematuria notable in his urinalysis. Further deterioration of his kidney function was noted with normal complement levels and ANCA panel.

TEE ruled out infective endocarditis vegetations. The patient developed NSTEMI during his hospital stay prompting a percutaneous coronary intervention of the right coronary and left circumflex arteries. The rash and joint pain improved completely while his residual kidney function remained stable. There was no immediate improvement of kidney function after the plasmapheresis course of 5 days.

The diagnosis can be easily missed. Accordingly, a high degree of suspicion and attention to noninvasive laboratory work culminating into kidney biopsy with immuno-fluorescence studies is mandatory to establish the diagnosis.

Adults with HSP carry a different prognosis, and the development of hematuria may be a harbinger for more serious complications such as nephritic or nephrotic syndrome. Malignancy is common in adult-onset HSP and imaging should be done to exclude this possibility.

Physicians should be aware of the possibility of HSP in patients who present with vasculitic rash and kidney disease. Normal complement level can distinguish between IgA nephropathy and vasculitis like granulomatosis with angiitis and lupus erythematosus.

Early diagnosis of HSP with kidney biopsy may improve the outcome. He had tachycardia, tachypnea, and fever with an erythematous, tender wound on left index finger. He had lacerated his finger 2 weeks prior with a pocket knife while cleaning dirt under his fingernail and failed cephalexin and clindamycin oral therapies prior to admission.

Intravenous broad spectrum vancomycin and piperacillin-tazobactam were initiated and subsequently blood cultures grew Pasteurella multocida. He lived on a farm with a cat. In view of the implanted cardiac device, fever and positive blood cultures, infective endocarditis was a concern. However, transthoracic echocardiogram did not reveal any vegetations. XR and bone scan imaging of his finger also ruled out osteomyelitis.

During his four days in the hospital, his condition and laboratory results improved and he was asymptomatic. Follow up blood cultures were negative and patient was discharged home on oral amoxicillin clavulanate for another week duration. Pasteurella multocida is a commensal gram-negative bacteria seen in the mouths of many domesticated animals that is the most common cause of cellulitis after an animal bite.

While it typically presents as soft tissue infections, it can more rarely cause meningitis, endocarditis, and bacteremia. It seems that contamination of the self-inflicted subungual minor wounds with cat saliva is what caused Pateurella multocida bacteremia. The patient also presented with splinter hemorrhages. This physical exam finding is caused by rupture of capillaries underneath the nail plate.

Blood attaches to the nail plate and moves distally as the nail grows, creating the characteristic linear pattern. While the association between splinter hemorrhages and endocarditis is often emphasized in medical training, they are present in other pathologies as well and in and of themselves do not constitute a criteria for endocarditis. They most commonly appear due to trauma, but are also seen in endocarditis, vasculitis, medications, and renal failure due to platelet dysfunction from buildup of uremic toxins as was likely the case in this patient.

The patient was unlikely to have endocarditis since he became asymptomatic in 2—3 days and tested negative in repeat blood culture. Although a transesophageal echocardiogram would have been beneficial in definitively ruling it out infective endocarditis, a transthoracic echo of good quality is adequate especially in persons with prompt clinical improvement. Although it primarily attacks the respiratory system, the extrapulmonary targets of the virus include the gastrointestinal tract and hepatobiliary system, among others.

A year-old male with a past medical history of coronary artery disease, hypertension, 0. He denied shortness of breath, cough, fever, or chills. Physical examination was significant for epigastric tenderness. Normal troponin. CXR on admission showed mild patchy bibasilar infiltrates suggestive of developing pneumonia. Right upper quadrant abdominal ultrasound showed no gallstones or other abnormalities within the pancreatobiliary system.

CT abdomen and chest with and without contrast showed evidence of acute pancreatitis and no other abnormalities. There is a limited but growing amount of literature supporting the diagnosis of SARS-CoV-2 induced viral pancreatitis. We worked up common causes of pancreatitis, and we do believe the patient presented with SARS-CoV-2 induced pancreatitis.

ACE2 is most abundantly expressed in the pulmonary sytem, but is also expressed in pancreatic cells as well as other cells in the gastrointestinal tract. This could explain a correlation between the virus and pancreatitis and other gastrointestinal symptoms. Although there is growing evidence of COVID-induced pancreatitis, the causal relationship is still debated between the two presentations.

Achondrogenesis Type II is an autosomal dominant lethal collagen disorder characterized by prominent forehead, recessed chin, small chest and ribs with resulting lung hypoplasia, enlarged abdomen, shortened limbs, and decreased ossification of the pelvis and spine due to pathologic variants of the COL2A1 gene.

The gene encodes for the pro-alpha1 chain, a key component of type II collagen which is necessary in developing the framework for embryologic skeletal development. The phenotype of achondrogenesis is variable, and that variation remains poorly understood.

Infant and mother presented after a detailed sonographic exam showed micromelia and polyhydramnios concerning for skeletal dysplasia. An amniocentesis was performed at 22 weeks gestation age wga was notable for a heterozygous missense mutation on the COL2A1 gene concerning for a collagenopathy. The infant was born at Upon delivery infant was noted to have high palate, protuberant abdomen, rhizomelic shortening of all extremities, sacral dysgenesis, and small thoracic cavity. He required intubation and mechanical ventilation immediately following delivery due to respiratory failure.

He has failed multiple attempts at extubation and has remained ventilator dependent since birth. He was initially considered to have a perinatally lethal disease phenotype due to upper airway obstruction and severe lung hypoplasia, however, after 6 months he may be considered as a tracheostomy candidate due to improved amount of lung tissue and continued survival.

The clinical and radiographic phenotype of achondrogenesis are widely varied and may place a significant burden on a family as the definition of perinatal lethality remains challenging.

The definition of lethality could be altered as a phenotype progresses with age. The number of skeletal dysplasias is growing rapidly due to technological advancements in genetic testing. A detailed description of this patient in the medical literature will aid the ongoing differentiation of the collagenopathy types. Skeletal dysplasias may be inherited via autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive, and Y-linked fashions.

Mutation can occur de novo or inherited. Early prenatal diagnosis helps to guide genetic and palliative discussions with families to determine postnatal treatment options and recurrence risk. Congenital dislocation of the spine CDS is a rare spinal malformation due to defective embryogenesis of the spine and spinal cord at a single level, that results in abrupt angulation of the spinal cord.

We report a rare case of congenital displacement of the spine in a neonate which was missed at first admission. An 8-day old Exweek old female infant was admitted to our neonatal intensive care unit due to concerns about a bump in the back. The infant was born to a year-old female via spontaneous vaginal delivery at an outside hospital. The prenatal course was unremarkable, all prenatal ultrasounds were reported as normal, and the mother was not on any medications during pregnancy except prenatal vitamins.

She was discharged from the delivery hospital after routine care. On follow-up exam with the primary care pediatrician, she was found to have a lump on the lower back. Spinal imaging including ultrasonography and magnetic resonance imaging were done which revealed posterior dislocation of L3 vertebral body relative to L2 with spinal cord compression.

She was admitted to the neonatal intensive care unit after neurosurgery consultation. On physical exam, the infant was noted to have bilateral talipes valgus deformity with an otherwise unremarkable neurological exam. On spinal exam, she had midline bony swelling step-up defect at L3 level with no other neurocutaneous findings.

Chromosomal microarray and whole-exome sequencing were normal. Posterior dislocation of L3 vertebral body relative to L2 with spinal cord compression. Although rare, congenital dislocation of the spine when diagnosed needs an immediate stabilization of the spine. Our case stresses the importance of a thorough spinal examination for appropriate diagnosis.

Human herpesvirus-6 HHV-6 is a beta herpesvirus found ubiquitously. However, establishing HHV-6 as a cause of meningitis or encephalitis may be challenging as a polymerase chain reaction PCR test alone does not imply causality. Examination revealed a clinically stable neonate. There was no CSF pleocytosis. After consult with infectious disease specialist, baby received IV Ganciclovir and repeat Biofire meningitis panel at 7 days continued to remain positive for HHV A decision was made to continue IV Ganciclovir for total of 21 days.

As the positive HHV6 was a serendipitous finding and the literature review showed possibility of lifelong latent infection the decision was made to discontinue Ganciclovir. Neonate was closely monitored as she was in the NICU with feeding issues and her counts recovered.

Baby remained asymptomatic and had an uneventful hospital course. A unique feature of HHV-6 is establishment of lifelong latency by integration into human chromosomes. If such integration occurs in a germ cell, it can be vertically transmitted to the fetus through chromosomal integration ciHHV With the advent of newer diagnostic tests like Biofire meningitis panel, there has been an increasing rate of detection of HHV-6 virus, but majority are not associated with encephalitis.

A positive test may either be due to chromosomal integration or subclinical reactivation of latent virus. Physicians caring for patients who test positive for HHV-6 on the Biofire panel should approach therapeutic decision making using all available information to minimize significant morbidity due to unnecessary use of antiviral agents, and emotional and financial burden associated with unwanted hospital stay. Disseminated Herpes Simplex Virus HSV is a feared neonatal infection typically presenting after the first week of life with sepsis-like features and encephalopathy.

Congenitally acquired HSV infection represents a rare, serious variety of HSV in the neonatal period, providing a unique diagnostic challenge with significant morbidity and mortality. A female infant was delivered at Physical exam at 1 hour of life demonstrated erosive lesions of the knee, foot, and cheek. Dermatology was consulted and favored infectious source of lesions, so a sepsis evaluation including HSV, VZV, and CMV studies was performed and ampicillin, gentamicin, acyclovir, and amphotericin B were started.

Given high concern for HSV vs. Laboratory evaluation revealed transaminitis, thrombocytosis, and CSF pleocytosis with elevated protein. The remainder of infectious studies were negative. Serial HUS showed initially normal findings that progressively worsened to feature bihemispheric cystic encephalomalacia, periventricular leukomalacia with ex vacuo dilation of lateral and third ventricles.

She developed central diabetes insipidus and was started on desmopressin. Ocular involvement subsequently included retinal necrosis and diffuse retinal hemorrhage. She developed severe myoclonic jerks in the absence of electrographic correlate on EEG. Levetiracetam and phenobarbital alleviated jerks, although she developed progressive hypotonia as neurologic status continued to deteriorate. Considering persistently positive HSV studies, foscarnet was added to acyclovir.

However, at 3 weeks of life, she was intubated for apnea and respiratory failure, and given clinical trajectory and devastating prognosis, mother asked to compassionately withdraw support and allow natural death on day of life This case of congenital, disseminated HSV is particularly unique in that it occurred in a premature infant of 29 weeks gestation and had significantly elevated copy numbers in the blood and CSF as well as skin lesions, indicating likely longstanding infection at the time of delivery.

This disorder often results from a GATA1 mutation, causing uncontrolled proliferation of blast cells, with spontaneous regression in most cases. Complications include thrombocytopenia, hepatosplenomegaly, pericardial and pleural effusions, and rarely tumor lysis syndrome TLS. We present the case of a late pre-term male infant, who at delivery had phenotypic features consistent with Trisomy 21, hepatosplenomegaly, and respiratory distress, prompting transfer to our facility.

Echocardiography revealed an atrial septal defect and pulmonary hypertension. The patient received supportive care with mechanical ventilation, intravenous hydration, Allopurinol, Rasburicase, packed red blood cells, cryoprecipitate, and fresh frozen plasma.

A double volume exchange transfusion was also performed. Despite aggressive management, he remained hypotensive with metabolic acidosis, hyperkalemia, and multi-organ failure succumbing to his disease, on day 2 of life, prior to chemotherapy. Most patients with TMD do not need cytotoxic drugs, as the process spontaneously resolves. However, symptomatic babies with high blast counts and organ dysfunction benefit from early interventions, including exchange transfusion and cytotoxic agents.

TLS is a complication of TMD which usually results from the rapid degradation of malignant cells after initiation of chemotherapy. Our case indicates that TLS can occur before the initiation of chemotherapy and can be fatal. Respiratory distress is a common clinical presentation seen in neonates. Common causes of respiratory distress in term neonates include, but are not limited to, transient tachypnea of newborn, infections, aspiration, or cardiac etiologies.

We present the rare case of a term infant who presented with an unusual cause of respiratory distress in newborn. Our patient was born at an outside facility to a year-old female who had poor prenatal care. Infant was delivered at 37 weeks gestation via emergent C-Section due to non-reassuring fetal heart rates.

He was noted to have an obvious chest wall deformity with a concavity to the right anterior chest and slight lateral curvature of thoracic vertebra. He was unable to maintain saturations on room air and had persistent tachypnea so was placed on supplemental oxygen and transferred to NICU.

Chest X-ray obtained at birth revealed multiple mid upper thoracic developmental vertebral body anomalies, diminished left thoracic volume and multiple bilateral rib fusion abnormalities. Blood work obtained was unremarkable with no concern for sepsis, metabolic conditions, or hematological issues.

He failed multiple attempts to wean off oxygen and would drop his saturations mostly when feeding. He was therefore transferred to our facility for higher level of care at two weeks of life.

On arrival to our NICU, Pulmonology was consulted, and further workup was obtained per their recommendations including a CT Chest which showed the known thoracic abnormality but no parenchymal or intrapulmonary processes. Modified Barium Swallow Study was negative for aspiration.

Echocardiogram showed a Patent Foramen Ovale but was otherwise normal. Cranial Ultrasound was normal and Abdominal Ultrasound showed a right pelvic kidney. Genetics was consulted, and genetic tests were obtained including chromosomal microarray which was normal and the working diagnosis was possible variant of Skeletal Dysplasia.

Since all other causes of respiratory distress were ruled out, his continual oxygen requirement was attributed to restrictive lung disease secondary to congenital chest wall deformity. He was unable to be weaned to room air and continued to be tachypneic on nasal cannula. He was eventually weaned off oxygen and at his last follow up at 9 months of age, he had been doing well on room air. He was referred to Pediatric Orthopedics and is scheduled for Expansion Thoracoplasty when he turns 1 year old.

Restrictive Lung Disease secondary to chest wall deformities can be a cause of respiratory distress in newborns. High flow nasal cannula is a newer means of home oxygen delivery and its use in this population is still evolving. A newborn female was delivered via elective C-section at 34 weeks due to maternal preeclampsia, growth restriction and a suspected right lung mass. Two doses of prenatal steroids were given to mother prior to delivery. The chest mass was noticed on a prenatal ultrasound which was followed by a fetal MRI.

However, the MRI did not reveal an abnormal chest mass but it was somewhat limited by motion of the fetus. Infant developed respiratory distress shortly after delivery and required CPAP for poor color and perfusion. Stat x-ray confirmed immature lungs with right lower chest mass. She was admittedto NICU and was promptly intubated due to increasing oxygen requirement.

Due to persistent respiratory distress and the size of the mass, decision was made to perform right upper lobectomy to release the compression. During the surgery, the patient was noticed to have total of 6 lobes of lung on the right side and 3 lobes looks abnormal. The abnormal lobes were intimately attached to the normal lobes. The patient had normal appearing upper, middle and lower lobes once the abnormal tissue was removed.

No aberrant vessel from any of the abnormal lobes to the aorta was seen. From the middle abnormal lung a frozen section biopsy was taken which showed cystic appearance close to the pleural surface up to 1.

Thoracotomy and resection of triple lobectomy was successfully performed on the 3-day old female and two chest tube was placed on the right side. Patient was remained to be on Jet Ventilation with chest tube to suction after surgery. She was then extubated and weaned to NIPPV one week later and both chest tubes were removed 2 weeks after surgery. Extra-lobar sequestration was confirmed presenting as three abnormal lobes, with histologic feature of CPAM type 2, but no aberrant vessel from any of the abnormal lobes to a systolic artery was seen.

A male infant was born at 28 weeks gestation to a G2P2 mother due to non-reassuring fetal status. Pregnancy was complicated by intractable seizures requiring induced coma, suspected chorioamnionitis, and insulin-dependent diabetes mellitus. Mother had epilepsy requiring multiple anti-epileptics.

At delivery, the baby was limp, edematous, and apneic requiring mechanical ventilation. He received surfactant for respiratory distress syndrome, dopamine for hypotension and antibiotics for presumed sepsis. On the third day of life, he was noted to have a systolic ejection murmur with widened pulse pressures. Echocardiogram showed multiple non-obstructive echogenic masses scattered over the myocardium of the ventricles, septum, and papillary muscles suggestive of rhabdomyomas. Due to maternal epilepsy and suspected cardiac rhabdomyomas, the diagnosis of familial tuberous sclerosis complex TSC was considered.

Neither mother nor infant had cutaneous findings. Mother had unremarkable head imaging. His cranial ultrasound showed nodular intraparenchymal echogenicity in bilateral subcortical frontal lobes suspicious for subcortical tubers and left lateral ventricle prominence with ependymal nodularity suspicious for a subependymal hamartoma. Renal ultrasound and ophthalmologic exam were unremarkable. TSC is a genetic disorder featuring the growth of benign tumors in multiple organ systems. Disease severity is variable and specific physical manifestations appear at progressive ages.

Often, mutations in TSC2 are associated with a more severe clinical course and developmental delay. Cardiac rhabdomyomas may lead to arrhythmias or outflow obstruction. Seizures typically present in infancy and can be difficult to control. Major criteria include hypomelatonic macules, angiobriomas, ungual fibromas, shagreen patch, retinal hamartomas, cortical tubers, subependymal nodules, subependymal giant cell astrocytoma, cardiac rhabdomyomas, lymphagioleiomyomatosis or angiomyolipmas.

Minor criteria include confetti skin lesions, dental enamel pits, intraoral fibromas, retinal achromatic patch, multiple renal cysts, nonrenal harmatomas and sclerotic bone lesions. The baby was diagnosed with TSC given his clinical findings. He was discharged at term without cutaneous findings or evidence of seizures. He will be followed by cardiology, genetics, ophthalmology, and the premature developmental follow-up clinic.

Congenital ectropion is an eversion of eyelid, where the skin of the lid is folded on itself, and conjunctival surface is exposed externally. The incidence is higher in black infants, Trisomy 21 syndrome, and in infants born with collodion skin disease. An early term female newborn was born to a 25 year old G3P2 mother of African ethnicity by vaginal delivery. Mother had adequate prenatal care with negative infectious prenatal labs.

Mother had spontaneous rupture of membranes lasting for 14 hours and a healthy-looking female baby was delivered without any complications. The underlying pupils or sclerae could not be visualized, and red reflex could not be performed. The eyeballs were palpated in the socket. Edematous upper palpebral conjunctiva was separated using eyelid retractors and underlying pupils and conjunctivae were noted to be normal in appearance.

Condition was diagnosed as bilateral congenital ectropion with severe chemosis. Hypertonic saline compresses over the eyelids were given for edema. On day of life 4, there was complete resolution of ectropion and normally appearing pupils and conjunctivae were noted.

Congenital ectropion is rarely reported in literature. Venous stasis, birth trauma and various abnormalities of muscles and ligaments of orbit including hypotonia of orbicularis muscle, vertical shortening of anterior lamella or vertical elongation of posterior lamella, failure of fusion of orbital septum with levator aponeurosis have all been proposed as possible mechanisms of congenital eversion.

Initially, eversion occurs only when the infant squeezes the eyelids shut during crying and resolve when the infant is calm. As edema increases, the eversion persists and may be difficult to reposition. The chemosed conjunctiva protects the underlying cornea and therefore, corneal complications are uncommon. Management strategies include both conservative and surgical approaches.

Surgical treatment includes tarsorrhaphy, fornix sutures and full thickness skin grafts to the upper eye lid. The condition resolves without any sequalae with prompt management, but delay in treatment can lead to complications including amblyopia, corneal ulcers, and permanent blindness.

Congenital eyelid eversion is a rare condition. A favorable clinical outcome may be expected with prompt diagnosis and intervention of this condition.

Knowledge of this condition with early intervention by clinicians may help in the prevention of complications that arise from poorly treated cases. Cystic hygroma was noted on the fetal ultrasound at 14 weeks. On physical exam at birth, she had pterygium colli and facial dysmorphism hypertelorism, downslanting palpebral fissures, posteriorly rotated low set ears.

She was admitted to the neonatal intensive care unit NICU due to respiratory distress. The patient was initially started on Ampicillin and Gentamicin for suspected sepsis. She had seizure-like activity on day two of life. Gentamicin was discontinued and a total of day course with Ampicillin and Ceftazidime was completed. Blood and CSF cultures were negative. EEG showed no seizure activity. Cranial ultrasound revealed hypoplastic corpus callosum, paucity of gyri, mild colpocephaly, cerebellar vermis hypoplasia, and wide extra-axial space.

RASopathy panel identified a pathogenic variant c. She also had splenomegaly. WBC count decreased and thrombocytopenia resolved after starting the treatment with 6-MP. JMML should be suspected in any patient with NS who has persistent leukocytosis with monocytosis and thrombocytopenia without evidence of an infectious process. A year-old sexually active female, presented with diffuse abdominal pain and distension. The symptoms were waxing and waning for a year. She denied recent travel. Family history of a breast canacer was reported.

On examination: Patient was vitally stable but appeared uncomfortable. Abdomen was markedly distended, dull to percussion with positive fluid thrill but bowel sounds were appreciable. Pelvic exam was negative for cervical tenderness or discharge. CRP 5. Liver enzymes, LDH and uric acid were normal. CBC unremarkable. CT scan abdomen-pelvis showed severe ascites with mesenteric omental caking. Working diagnosis was peritoneal carcinomatosis vs tuberculous peritonitis.

TB workup was negative. Laparoscopy showed pelvic inflammation around the uterus with abscess and benign lymph nodes.

Pelvic inflammatory disease PID was presumed as the cause of ascites. Patient was started on intravenous antibiotics. Symptoms resolved and the patient was discharged on Doxycycline and Metronidazole. Although the majority of females with CT infection are asymptomatic, CT known to cause urethritis, salpingitis, and cervicitis.

Ascites was rarely reported as the only presenting symptom of CT. Exudative ascetic fluid and predominance of lymphocytes were noted in all reported CT cases with ascites. Hospitalization with parenteral antibiotic for 1—2 days is recommended for severe PID. Clindamycin or metronidazole should be used when tubo-ovarian abscess present.

CT abdomen-pelvis: White arrow pointing towards fluid collection in the abdominal cavity. Appropriate testing should be pursued early in the workup of these patients. Transverse myelitis is the segmental inflammation of the spinal cord with motor and sensory abnormalities at and below the level of the lesion.

Often, the etiology is unknown but may be attributed to autoimmune conditions or viruses. A 5-year-old male with a history of asthma presented for vomiting and altered mental status. The patient was noted to be altered, lethargic, and in respiratory distress. Intubation was performed. History also revealed that he had slurred speech, ataxia, and a fall with trauma to forehead 1 day prior to arrival.

Dexamethasone was started. When sedation was weaned in hopes of extubation, patient was noted to be alert, but not moving extremities and had minimal gag and cough reflex. MRI of Brain and Spine were conducted and revealed findings suggestive of long segment transverse myelitis involving C2 to C3.

Further, patient underwent ten sessions of plasmapheresis. Repeat MRI was consistent with previous. Physical and occupational therapy initiated at the onset of illness in hopes of achieving musculoskeletal improvement. Patient had some minimal musculoskeletal improvement, however, given his condition, decision was made for patient to undergo placement of gastrostomy and tracheostomy tubes.

Patient was weaned off of sedatives and withdrawal was treated with a clonidine taper. Once stabilized, patient was transferred to neurological inpatient rehabilitation center. Pathophysiology is multifactorial, including direct invasion of the CNS, vascular insufficiency, immune dysregulation and autoimmunity.

Imaging is paramount in the diagnosis of transverse myelitis. Treatments are emerging and may include steroids, immunoglobulin, plasmapheresis, and monoclonal antibodies. Information is emerging and evolving daily. Cases of transverse myelitis in COVID have been reported in few adult patients and minimal pediatric patients. Practitioners should keep transverse myelitis on their list of differentials for neurological complications of SARS-CoV-2 infections and initiate aggressive treatment with a multidisciplinary approach.

This is a case of partial retinal artery occlusion in an adolescent. She denied any trauma, redness, excessive tearing, discharge, floaters, vomiting, fever or headaches. Her family history was unknown as patient was an adopted child. Her initial external ocular, including intraocular pressure, and remainder of the neurologic exams were normal.

Retinal edema along the superotemporal arcade on the right was noted during a dilated fundoscopic examination by Ophthalmology, concerning for branched retinal artery occlusion BRAO. Transthoracic echocardiogram showed trivial tricuspid and mitral valves insufficiency, but was otherwise normal with an intact interventricular septum, no atrial septal defect, and no thrombus. She was discharged home on daily Aspirin with close outpatient follow-up with Ophthalmology and Neurology. The central retinal artery is a branch of the ophthalmic artery, which itself is a branch of the internal carotid artery.

It enters the eye at the optic disc and divides into smaller branches to supply the inner layers of the retina. An occlusion of the central artery or any of its branches leading to retinal ischemia is defined by sudden painless monocular vision loss.

Men are more commonly affected than women. Potential etiologies include carotid artery atherosclerosis, cardiogenic embolism, vascular disease, hematologic disease such as hypercoagulable state, inflammatory disease such as giant cell arteritis and polyarteritis nodosa, and infection.

Although carotid artery atherosclerotic disease is the most common cause overall, it is unusual under the age of 40, when cardiogenic embolism is the most common cause. Patients with BRAO typically complain of monocular visual loss, which may be restricted to just part of the visual field.

Diagnostic work-up focuses on identifying the underlying etiology. It includes carotid artery imaging, cardiac evaluation, and hypercoagulable testing.

In the case of our patient, her BRAO remains of unknown etiology as all of her inpatient work-up yielded normal results. Further testing is currently ongoing. Chickenpox is a highly contagious viral infection due to the varicella zoster virus.

Primary infection in young children typically presents as a cutaneous, self-limited disease. Prior to the introduction of the varicella vaccine in , roughly 4 million people contracted chickenpox each year.

The vaccine led to a reduction in rates of infection, hospitalizations, and mortality. Today, fewer than , people contract chickenpox yearly. However, breakthrough infections in vaccinated individuals still occurs in approximately 13 per , individuals. Below, we discuss the case of a vaccinated 9 year old female with a superimposed bacterial infection secondary to chickenpox.

A fully vaccinated 9 year old female was transferred from an outside hospital for worsening cellulitis of her right upper extremity. Two weeks prior to admission she was treated with 10 days of oral clindamycin for cellulitis of her face, chest, and right arm with clinical improvement.

Four days after resolution of the cellulitis she developed a new pruritic papule on her right arm. Her sister had several similar lesions which resolved within 48 hours. Our patient developed progressive erythema of her right antecubital fossa with evolution to a large, serum crusted plaque. Pruritic vesicles developed on her face, abdomen, and legs.

 
 

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Hi. Yesterday I downloaded Audirvana (free trial for windows 10). I have a DAC – Chord QuTest. In the settings of AppSampling I choose DSD. Audirvāna Studio. The High Resolution digital audio player. Enjoy all your streaming and local music with the best playback sound quality. Free trial.
 
 

 

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All softwares, firmwares are up to date. What you’re saying would be quite plausible I hear popping sound 2 pops when I start playing DSD file. For instance, CD quality, If you stream Qobuz you want to go to custom filters and you can choose not up sample or to up- sample. Whether it is also true in practice…….? Even Volumio is reporting it as DSD although it doesn’t say what it does with it.

 
 

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